Catalog Products » Immune Checkpoint Antibodies and Proteins

Overview

Immune checkpoint-blocking antibodies that activate the immune system to fight cancer are becoming an important method of cancer treatment. CTLA-4 was the first immune checkpoint target and ipilimumab, an anti CTLA-4 antibody drug, was approved in 2011 for clinical use. The PD-1 receptor and its ligand PD-L1 have shown great promise as therapeutic targets in a variety of malignancies. The combined- target immunotherapy may have a higher level of effect in the future.

To facilitate this hot immunotherapy research field, GenScript provides immune checkpoint antibodies and proteins for many kinds of applications. Products for more targets are coming in succession.

  • Product Details

  • Selection Guide

  • Drug Candidate Antibody

    Application

    Positive control of antibody drug development

    For cell line development

    For assay development

    Target Cat.No. Product Name ELISA FACS Functional Assay
    PD1
    A01828-40
    Human PD1 Antibody (16H5), mAb, Mouse
    ✔
    ✔
    ✔
    A01829-40
    Human PD1 Antibody (61D3), mAb, Mouse
    ✔
    ✔
    ✔
    PDL1
    A01830-40
    Human PDL1 Antibody (21D1), mAb, Mouse
    ✔
    ✔
    ✔
    A01831-40
    Human PDL1 Antibody (30A6), mAb, Mouse
    ✔
    ✔
    ✔
    CTLA-4
    A01832-40
    Human CTLA-4 Antibody (Clone A), mAb, Mouse
    ✔
    ✔
    ✔
    A01833-40
    Human CTLA-4 Antibody (Clone B), mAb, Mouse
    ✔
    ✔
    ✔
    TIM3
    A01834-40
    Human TIM3 Antibody (Clone A), mAb, Mouse
    ✔
    ✔
    A01835-40
    Human TIM3 Antibody (Clone B), mAb, Mouse
    ✔
    ✔
    LAG3
    A01836-40
    Human LAG3 Antibody (Clone A), mAb, Mouse
    		 
    A01837-40
    Human LAG3 Antibody (Clone B), mAb, Mouse
    		 
  • Surrogate Antibody

    Application

    For target validation

    Combo therapy evaluation

    Target Cat.No. Product Name ELISA FACS Functional Assay
    PD1
    A01838-40
    Mouse PD1 Antibody (9D5), mAb, Mouse
    ✔
    A01839-40
    Mouse PD1 Antibody (15A8), mAb, Mouse
    ✔
    PDL1
    A01840-40
    Mouse PDL1 Antibody (44E2), mAb, Mouse
    ✔
    A01841-40
    Mouse PDL1 Antibody (44E9), mAb, Mouse
    ✔
    CTLA-4
    A01842-40
    Mouse CTLA-4 Antibody (Clone A), mAb, Mouse
    ✔
    A01843-40
    Mouse CTLA-4 Antibody (Clone B), mAb, Mouse
    ✔
  • Anti-idiotype Antibody

    Application

    Bioanalytical Method Development (PK/PD)

    Immunogenicity study

    Target Cat.No. Product Name ELISA FACS Functional Assay
    Pembrolizumab
    A01844-40
    Anti-Pembrolizumab/ (Keytruda), mAb clone A
    ✔
    A01845-40
    Anti-Pembrolizumab/ (Keytruda), mAb clone B
    ✔
    A01846-40
    Anti-Pembrolizumab/ (Keytruda), pAb, Rabbit
    ✔
    Nivolumab
    A01847-40
    Anti-Nivolumab/ (Opdivo), mAb clone A
    ✔
    A01848-40
    Anti-Nivolumab/ (Opdivo), mAb clone B
    ✔

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