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AXL, His, Cynomolgus

Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
$340.00
Z04737-100

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Product Introduction
Species Cynomolgus
Protein Construction
AXL (Glu33-Pro449)
Accession # A0A1D5Q330		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 46.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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AXL, His, Cynomolgus

Immobilized AXL, His, Cynomolgus, His Tag at 0.5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-AXL Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA. »

AXL, His, Cynomolgus

The purity of AXL, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

AXL, His, Cynomolgus

AXL, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

AXL, His, Cynomolgus

AXL, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus GAS6, His Tag with an affinity constant of 1.70 nM as determined in SPR assay (Biacore T200). »

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Background
Target Background Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
Synonyms Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; AI323647; EC 2.7.10; EC 2.7.10.1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.