Catalog Products » CA125/MUC16, His, Human
Manual
Manual
COAs

CA125/MUC16, His, Human

MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
$390.00
Z04037-100

Ask us a question
Product Introduction
Species Human
Protein Construction
CA125/MUC16 (Asp12783-Ser13467)
Accession # Q8WXI7		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CA125/MUC16, His, Human at 1μg/ml (100μl/well) on the plate can bind Human MSLN, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 76.17 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
Back

CA125/MUC16, His, Human

Immobilized CA125/MUC16, His, Human, His Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Human MSLN, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. »

CA125/MUC16, His, Human

CA125/MUC16, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

<
>

Background
Target Background MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
Synonyms CA125; CA-125; CA125MUC-16; FLJ14303; MUC16
Back

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.